Nucleotide sequence of a variant protein A of Staphylococcus aureus suggests molecular heterogeneity among strains
✍ Scribed by Marcelo De Macedo Brígido; Célia Regina Monte Barardi; Claudio A. Bonjardin; Cecília Luiza Simões Santos; Maria De Lourdes Junqueira; Dr. Ricardo Renzo Brentani
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 639 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0233-111X
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✦ Synopsis
Protein A is a cell wall linked protein of Staphylococcus aureus that binds mammalian IgG. Although protein A displays high size heterogeneity among strains, cloning and sequencing of its gene from two strains had not shown a large difference in size. Here we report a third protein A gene sequence that shows a size variation relative to these two, due to deletions on both one IgG binding domain and a cell wall binding domain (region X). By analysis of the three sequences we were able to delineate a hypothetic model for region X domain evolution and discussed the origin of genetic variability within and without strains.