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Nucleotide sequence analysis of a full-length human T-cell leukemia virus type I from adult T-cell leukemia cells: A prematurely terminated PX open reading frame II

โœ Scribed by Kuan S.Chou; Akihiko Okayama; Nobuyoshi Tachibana; Tun-Hou Lee; Max Essex

Book ID
102870011
Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
684 KB
Volume
60
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Human T-cell leukemia virus type I (HTLV-I) is etiologically associated with adult T-cell leukemia/lymphoma (ATL). The prototypic HTLV-I, ATK, is the only full-length provirus cloned from uncultured leukemic cells and completely sequenced prior to this study. We have determined the complete nucleotide sequence of another full-length HTLV-I provirus cloned directly from leukemic cells. A premature termination codon was found in the second open reading frame (orf It) of the pX region. Our finding indicates that open reading frame II of the HTLV-I pX region is not required for outgrowth of ATL leukemic clones in vivo.

๐Ÿ“œ SIMILAR VOLUMES

Preferred nucleotide sequence at the int
Preferred nucleotide sequence at the integration target site of human T-cell leukemia virus type I from patients with adult T-cell leukemia
โœ Kuan S. Chou; Akihiko Okayama; Ih-Jen Su; Tun-Hou Lee; Max Essex ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 581 KB

Human T-cell leukemia virus type I (HTLV-I) is etiologically associated with adult T-cell leukemia/lymphoma (ATL). We cloned and sequenced host DNA adjacent to the long terminal repeats of HTLV-I from uncultured leukemic cells of 4 ATL patients. The region flanking the provirus was generally A/Trich