𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Nucleotide Delivery from cycloSaligenyl-3′-azido-3′-deoxythymidine Monophosphates (cycloSal-AZTMP)

✍ Scribed by Chris Meier; Eric De Clercq; Jan Balzarini

Book ID
102657844
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
560 KB
Volume
1998
Category
Article
ISSN
1434-193X

No coin nor oath required. For personal study only.

✦ Synopsis

AZT / cycloSal-pro-nucleotide / Prodrugs / Nucleotide delivery / HIV chemotherapy

The application of our cycloSaligenyl-(cycloSal) pronucleotide concept to the approved anti-HIV dideoxynucleoside 3Ј-azido-3Ј-deoxythymidine AZT (1) is reported. This pronucleotide concept has been designed to deliver the corresponding 3Ј-azido-3Ј-deoxythymidine monophosphate AZTMP (2) by selective chemical hydrolysis from the lipophilic precursors cycloSal-AZTMP 4a؊h. All derivatives 4a؊h were synthesized using differently substituted salicyl alcohols 7a؊h as starting materials. In hydrolysis studies,

📜 SIMILAR VOLUMES

ChemInform Abstract: cyclo-Saligenyl-3′-
ChemInform Abstract: cyclo-Saligenyl-3′-azido-2′,3′-dideoxy-thymidinemonophosphate ( cycloSal-AZTMP) - A New Pro-Nucleotide Approach?
✍ C. MEIER; E. DE CLERCQ; J. BALZARINI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v