๐”– Bobbio Scriptorium
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Nucleotide changes in oxidatively stressed lymphocytes

โœ Scribed by Palace, Gerard P. ;Lawrence, David A.

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
587 KB
Volume
10
Category
Article
ISSN
0887-2082

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โœฆ Synopsis

Similar to HIV-1-induced suppression of thymus-derived lymphocytes (T cells), oxidatively stressed T cells show inhibited DNA synthesis and proliferation. The influence of oxidative stress on nucleotide pools was explored using 'Huridine addition to OKT3-stimulated peripheral blood lymphocytes. The cells were preincubated and stimulated in the presence of 1 mM buthionine sulfoximine to inhibit GSH synthesis. This treatment gave rise to a significant reductfon -in dUDP and TTP biosynthesis following 18-32 hours stimulation, indicating possible impairment of ri- bonucleotide reductase activity.

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