Nucleotide analogs as novel anti-hepatitis B virus agents
β Scribed by Radhakrishnan P Iyer; Seetharamaiyer Padmanabhan; Guangrong Zhang; John D Morrey; Brent E Korba
- Book ID
- 116383375
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 227 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1471-4892
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In order to study the structure-activity relationships, several dioxolane pyrimidine nucleosides have been synthesized and their anti-HBV activities have been evaluated in 2.2.15 cells. From the study it was found that 5-fluoro-cytosine derivatives exhibited the most potent anti-HBV activity. Recen
## Abstract The nucleotide sequences of the precore/core and X open reading frames (ORFs) of hepatitis B virus (HBV) were studied in four subjects who were serologically negative for antiβhepatitis B core antibody. These subjects were positive for serum hepatitis B surface antigen and were consider