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Nucleosome DNA Sequence Pattern Revealed by Multiple Alignment of Experimentally Mapped Sequences

✍ Scribed by Ilya Ioshikhes; Alex Bolshoy; Konstantin Derenshteyn; Mark Borodovsky; Edward N. Trifonov


Book ID
115627524
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
199 KB
Volume
262
Category
Article
ISSN
0022-2836

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We have studied the relationship between amino acid sequence and substrate specificity in a DNA glycosylase family by characterizing experimentally the specificity of four new members of the family. We show that principal component analysis (PCA) of the sequence family correctly predicts the substra