Nucleosides and nucleotides. XLVII. Conformation of purine mucleosides and their 5'-phosphates
โ Scribed by Ikehara, Morio; Uesugi, Seiichi; Yoshida, Katsumi
- Book ID
- 120426034
- Publisher
- American Chemical Society
- Year
- 1972
- Tongue
- English
- Weight
- 654 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0006-2960
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The synthesis of ring-expanded imidazo [4,5-c]azepine nucleosides (3-6) is described. Treatment of 5-iodoimidazole derivative 9 with methyl acrylate in the presence of a palladium catalyst gave (E)-5-(2-carbomethoxyvinyl)-1-(2,3,5-tri-O-acetyl-13-Dribofuranosyl)imidazole-4-carboxamide (10), appropri
Nucleosides and Nucleotides. Part 179. Ring-Expanded Purine Nucleosides. The Synthesis and Cytotoxicity of Imidazo[4,5-c]azepine Nucleosides. -Title compounds (V), (IX), (XVIII), and (XIX) are prepared and tested for cytotoxic activity. Only (XVIII) shows small activity.