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Nucleosides and Nucleotides as Potential Therapeutic Agents

✍ Scribed by Dr. T. Y. Shen

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
966 KB
Volume
9
Category
Article
ISSN
0044-8249

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✦ Synopsis

Abstract

The present article summarizes recent progress in the study of nucleoside derivatives as antiviral and immunosuppressive agents. A number of 5′‐substituted 5′‐deoxy nucleosides have been found to be permeable and nonincorporable antimetabolites of 5′‐nucleotides. N^6^‐isopentenyladenosine and analogs show certain promising immunosuppressive activities. Encouraged by the antibody‐stimulating effect of oligonucleotides, we have developed a convenient synthesis of oligonucleotides using fully protected phosphorylated intermediates. A group of tetradeoxyribonucleotides, dApdApdApdX, was prepared for biological and physical evaluations. Nucleotide derivatives may prove valuable in the treatment of several immunological disorders.

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Therapeutic potential of nucleoside/nucl
Therapeutic potential of nucleoside/nucleotide analogues against poxvirus infections
✍ Professor Erik De Clercq; Johan Neyts 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 287 KB

## Abstract Several nucleoside and nucleotide analogues have been identified as potent antiviral agents with convincing activity against poxviruses (including variola, vaccinia, monkeypox, cowpox, molluscum contagiosum, orf). Among the nucleoside analogues, 8‐methyladenosine and 2‐amino‐7‐[(1,3‐dih