✦ LIBER ✦
Nucleosides and nucleotides. 161. Incorporation of 5-(N-aminoalkyl)carbamoyl-2′-deoxycytidines into oligodeoxyribonucleotides by a convenient post-synthetic modification method
✍ Scribed by Yukari Nomura; Noriyasu Haginoya; Yoshihito Ueno; Akira Matsuda
- Book ID
- 104364665
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 336 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
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✦ Synopsis
5-Trifluoroethoxycarbonyl-2'-deoxycytidine derivatives were synthesized and incorporated into oligonucleotides. The fully protected oligonucleotides were treated with diaminoethane or 1.6-diaminohexane to give oligonucleotides carrying amino-linkers, which were further derivatized with an intercalator. The properties of these oligonucleotides are described.