Nucleoside conjugates V: Synthesis and biological activity of 9-(β-d-arabinofuranosyl)adenine conjugates of corticosteroids
✍ Scribed by Chung Il Hong; Alan J. Kirisits; Alexander Nechaev; David J. Buchheit; Charles R. West
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 399 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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## Abstract The anticancer effects of 9‐β‐(2′‐azido‐2′‐deoxy‐D‐arabinofuranosyl)adenine (arazide) were compared to those of 9‐β‐D‐arabinofuranosyladenine (araA) in P388 leukemia cells. Arazide was less susceptible than araA to deamination by a partially purified preparation of adenosine deaminase f
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Naturally occurring nucleosides, nucleoside antibiotics, and their analogues are compounds of increasing importance and interest as antitumor and antiviral agents. 3 In particular, araA (9-8-g-arabinofuranosyladenine, 1) exerts inhibi--4 tory activity against various tumor lines and against DNA vir