Nucleoside Analogues with a 1,4-Dioxane, 1,4-Oxathiane or 1,4-Oxazine Ring Structure as the Carbohydrate Fragment
✍ Scribed by Arthur van Aerschot; Gerard Janssen; Piet Herdewijn
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Weight
- 568 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0037-9646
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## Abstract The synthesis of a novel ring‐expanded nucleoside analogue, (Z)‐1‐((2‐Guanidinocarbamoyl‐cyclopropylidene)methyl)‐4,5,7,8‐tetrahydro‐6__H__‐6‐iminoimidazo[4,5‐__e__][1,3]diazepine‐4,8‐dione (**1**) has been reported. It was prepared starting from methyl imidazole‐4,5‐dicarboxylate by se
## Abstract magnified image The cyclization mechanism for the title compound (**2**) reacting with one‐carbon fragment reagents or nitrous acid to afford heterobicyclic compounds 6‐amino‐3‐substituted‐1,2,4‐triazolo[3,4‐__f__][1,2,4]triazin‐8(7__H__)‐ones (**3a∼d**) or 6‐amino‐1,2,3,4‐tetrazolo[5,