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Nucleoside analog ARC targets Mcl-1 to induce apoptosis in leukemia cells

✍ Scribed by Bhat, U G; Gartel, A L

Book ID
109887335
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
492 KB
Volume
24
Category
Article
ISSN
0887-6924

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## Abstract In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall survival rate. Cisplatin exposure of sensitive cells has been previously associated with a down‐regulation of Bcl‐X~L~ expression a