Nucleophilic Substitution in the Allyl System of Codeine and Pseudocodeine in their Reactions with Lithium Methyl- and Aryl-cyanocuprates. Crystal and Molecular Structure of 8α-Phenyl-6,7-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan and 6β-Phenyl-7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan

Nucleophilic Substitution in the Allylic

Nucleophilic Substitution in the Allylic System of Codeine and Pseudocodeine: Reactions with lithium cyano(methyl)-and (aryl)cyanocuprates. Crystal and molecular structure of 8α-phenyl-6,7-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan and 6α-phenyl-7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan

✍ Valery N. Kalinin; Irina L. Belyakova; Vladimir V. Derunov; Pavel V. Petrovskii; 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 German ⚖ 363 KB

## 9. VIII.93) Nucleophilic substitution of 6p-chloro-7,8-didehydro-4,5~ -epoxy-3-methoxy-17-rnethylmorphinan (1) and 8a -brom0-6,7-didehydro-4,5~ -epoxy-3-methoxy-17-methylmorphinan (2) with lithium cyano(methy1)-and (aryl)cyanocuprates(I) (5a-c) was accompanied by allylic rearrangement with both