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Nucleophilic displacements of 3-substituents in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridines

✍ Scribed by Lyle, Robert E.; Krueger, William E.


Book ID
124082820
Publisher
American Chemical Society
Year
1967
Tongue
English
Weight
589 KB
Volume
32
Category
Article
ISSN
0022-3263

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP