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Nucleolar changes induced in TG cells by camptothecin, an inhibitor of topoisomerase I activity

✍ Scribed by Derenzini, Massimo; Parabegoli, Fulvia; Molnar, Margherita; Marzia, Govoni; Novello, Francesco


Book ID
122257668
Publisher
Portland Press
Year
1988
Tongue
English
Weight
131 KB
Volume
63
Category
Article
ISSN
0248-4900

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## Abstract Camptothecin (CPT) and actinomicyn‐induced strand‐breaks, repair and apoptosis in unstimulated human blood cells were studied using the DNA comet assay, and electrophoresis of low molecular weight DNA extracts. On the one hand, incubation of G0 leukocytes for 1h with CPT induced DNA str