Nucleic acid related compounds. 43. A convenient procedure for the synthesis of 2′ and 3′-ketonucleosides
✍ Scribed by Fritz Hansske; Morris J. Robins
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 222 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Chromium trioxide/pyridine/acetic anhydride effects smooth oxidation of selectively protected nucleosides to give high yields of 2' or 3'-ketonucleosides, whose reduction provides the inverted nucleoside epimers.
📜 SIMILAR VOLUMES
Oxidation of 2',5'-and 3',5'-0.(terr-butyldimethylsilyl)-protected ribonucleosides gave rhe corresponding 3'-keto and 2'-keto derivatives, whose complete oxidation was assayed by total release of the heterocyclic base upon treatment with tetrabutylammonium fluoride/THF. Treatment of the protected ke
## Abstract (Z)‐3‐(α‐Alkoxycarbonyl‐α‐cyanomethylene)‐2‐oxo‐1,2,3,4‐tetrahydroquinoxalines 3 and (Z)‐3‐(α‐alkoxycarbonyl‐α‐cyanomethylene)‐3,4‐dihydrobenzo[__g__]quinoxalin‐2(1__H__)‐ones 5 possessing various alkoxycarbonyl groups were prepared in good yields directly from the reaction of dialkyl (