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Nuclear Ubiquitin Ligases, NF- B Degradation, and the Control of Inflammation

✍ Scribed by Natoli, G.; Chiocca, S.


Book ID
118070663
Publisher
American Association for the Advancement of Science (AAAS)
Year
2008
Tongue
English
Weight
476 KB
Volume
1
Category
Article
ISSN
1945-0877

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Transcriptional factor nuclear factor-kappaB (NF-kB) plays a crucial role in human breast cancer cell invasion and metastasis. The carboxyl terminus of Hsc70-interacting protein (CHIP) is a U-box-type ubiquitin ligase that induces ubiquitination and proteasomal degradation of its substrate proteins.