✦ LIBER ✦

Nuclear transplantation in mammals: Remodelling of transplanted nuclei under the influence of maturation promoting factor

✍ Scribed by Josef Fulka Jr; Neal L. First; Robert M. Moor

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 912 KB
Volume: 18
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950181010

No coin nor oath required. For personal study only.

✦ Synopsis

Whilst the role of Maturation or M-phase Promoting Factor (MPF) as a universal M-phase regulator is well documented, much less attention has been paid to its role in nuclear transplantation experiments and especially to its influence upon remodelling of transplanted nuclei. There is currently wide acceptance that successful nuclear transplantation using differentiated nuclei is possible only in a cytoplasmic environment that is capable of inducing rapid nuclear dedifferentiation to a pronuclear-like form. In this review our purpose is firstly, to outline the conditions under which such remodelling can be induced, and secondly, to extend the debate to include a consideration of whether complete Accepted nuclear remodelling is an absolute necessity for clonal development.

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