Nuclear texture analysis: A new prognostic tool in metastatic prostate cancer

✍ Scribed by Trond Jørgensen; Kanagasingam Yogesan; Kjell J. Tveter; Fredrik Skjørten; Håvard E. Danielsen

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 691 KB
• Volume: 24
• Category: Article
• ISSN: 0196-4763
• DOI: 10.1002/(sici)1097-0320(19960701)24:3<277::aid-cyto11>3.0.co;2-n

✦ Synopsis

This report describes the prognostic d u e of computerized nuclear texture analysis in metastatic prostate cancer. Seventy-seven patients with histologically verified prostate carcinomas and skeletal metastases were selected from a Scandinavian multicenter study (SPCG-2). Thirty-sh therapy-resistant patients experienced objective progression and cancer-related death within 2 years after orchiectomy. Thirty patients responded well to orchiectomy, i.e., showed objective dkase remission and no signs of progression during 3 years of follow-up. From this data set, 10 randomly chosen therapy-resistant and 10 randomly chosen therapy-sensitive carcinomas were used in our previous study to find the optimal combination of features that can discriminate between the two groups (Yogesan et al.: Cytom-This work was supported by the Norwegian Cancer Society. The authors thank the following Hospital Departments of Urology and Pathology for their support in lending us histological sections and paraffin blocks: in