Nuclear Signaling by Receptor Tyrosine Kinases: The First Robin of Spring
β Scribed by Joseph Schlessinger; Mark A. Lemmon
- Book ID
- 116353263
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 282 KB
- Volume
- 127
- Category
- Article
- ISSN
- 0092-8674
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Cell proliferation in response to growth factors is mediated by specific high affinity receptors. Ligand-binding by receptors of the protein tyrosine kinase family results in the stimulation of several intracellular signal transduction pathways. Key signalling enzymes are recruited to the plasma mem
Intracellular signaling proteins are very often regulated by site-specific phosphorylation. For example, growth factor receptors in eukaryotic cells contain intrinsic tyrosine kinase activity and use inter- and intra-molecular interactions to recruit and orient potential protein substrates for phosp