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Nuclear proteome analysis of benzo(a)pyrene-treated HeLa cells

✍ Scribed by Chunlan Yan; Zhaojun Chen; Huanrong Li; Guanglin Zhang; Feng Li; Penelope J. Duerksen-Hughes; Xinqiang Zhu; Jun Yang

Book ID: 113809622
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 851 KB
Volume: 731
Category: Article
ISSN: 0027-5107
DOI: 10.1016/j.mrfmmm.2011.11.007

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## Abstract Hamster embryo cells metabolize benzo(a)pyrene to derivatives that covalently modify nuclear macromolecules including proteins. Not all proteins are modified to the same extent nor by the same metabolites. In particular, a protein of apparent molecular weight 32,000 is highly modified b