𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Nuclear protein isoforms: Implications for cancer diagnosis and therapy

✍ Scribed by Fei Shen; Kashif Z. Kirmani; Zhimin Xiao; Benjamin H. Thirlby; Robert J. Hickey; Linda H. Malkas

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
73 KB
Volume
112
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Post‐translational modifications (PTMs) of nuclear proteins play essential roles in the regulation of gene transcription and signal transduction pathways. Numerous studies have demonstrated a correlation between specific nuclear protein isoforms and cellular malignant process. This communication reviews the impact of major PTM events such as phosphorylation, acetylation, methylation, ubiquitination, and sumoylation on several important nuclear proteins including p53, histones, proliferating cellular nuclear antigen (PCNA), and retinoblastoma protein (Rb) in the process. In addition, the implications of the PTMs as cancer biomarkers and therapeutic targets are considered. J. Cell. Biochem. 112: 756–760, 2011. Β© 2010 Wiley‐Liss, Inc.

πŸ“œ SIMILAR VOLUMES

Radiation therapy for prostate cancer lo
Radiation therapy for prostate cancer long-term results and implications for future advances
✍ Ronald D. Ennis; Richard E. Peschel πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 655 KB

Background. There are surprisingly few studies that concurrently report the 10-year overall survival (0s) rate, 10-year adjusted survival (AS) rate, 10-year recurrence free (NED) survival rate, and 10-year local tumor control (LC) rate using external beam radiation therapy (RT) for Stages AZ, B, and

Regulation of androgen receptor levels:
Regulation of androgen receptor levels: Implications for prostate cancer progression and therapy
✍ Kerry L. Burnstein πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 158 KB πŸ‘ 3 views

## Abstract Androgen deprivation has been the standard therapy for advanced and metastatic prostate cancer for over half a century, as prostate tumors are initially dependent on androgens for growth and survival. Unfortunately, in most patients undergoing androgen ablation, relapse (recurrent tumor