Nuclear Pore Complexes in Genome Organization, Function and Maintenance

✍ Scribed by Maximiliano D’Angelo (eds.)

• Publisher: Springer International Publishing
• Year: 2018
• Tongue: English
• Leaves: 245
• Edition: 1
• Category: Library

✦ Synopsis

The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome.

✦ Table of Contents

Front Matter ....Pages i-viii
Spatial Organization of the Nucleus Compartmentalizes and Regulates the Genome (Michael I. Robson, Andrea Rizzotto, Eric C. Schirmer)....Pages 1-34
The Molecular Composition and Function of the Nuclear Periphery and Its Impact on the Genome (C. Patrick Lusk, Megan C. King)....Pages 35-62
Nuclear Pore Complexes: Fascinating Nucleocytoplasmic Checkpoints (Victor Shahin)....Pages 63-86
Nuclear Pore Complex in Genome Organization and Gene Expression in Yeast (Carlo Randise-Hinchliff, Jason H. Brickner)....Pages 87-109
Nuclear Pore and Genome Organization and Gene Expression in Drosophila (Terra Kuhn, Maya Capelson)....Pages 111-135
Caenorhabditis elegans Nuclear Pore Complexes in Genome Organization and Gene Expression (Celia María Muñoz-Jiménez, Peter Askjaer)....Pages 137-158
Nuclear Pore Complexes in the Organization and Regulation of the Mammalian Genome (Marcela Raices, Maximiliano A. D’Angelo)....Pages 159-182
Nuclear Pore Complexes, Genome Organization and HIV-1 Infection (Francesca Di Nunzio)....Pages 183-199
Nuclear Pore Complexes in DNA Repair and Telomere Maintenance (Marie-Noelle Simon, Alkmini Kalousi, Evi Soutoglou, Vincent Géli, Catherine Dargemont)....Pages 201-218
NPCs in Mitosis and Chromosome Segregation (Masaharu Hazawa, Akiko Kobayashi, Richard W. Wong)....Pages 219-240

✦ Subjects

Gene Function