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Nuclear neighbours: The spatial and functional organization of genes and nuclear domains

✍ Scribed by Wouter Schul; Luitzen de Jong; Roel van Driel

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 363 KB
Volume: 70
Category: Article
ISSN: 0730-2312
DOI: 10.1002/(sici)1097-4644(19980801)70:2<159::aid-jcb2>3.0.co;2-n

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✦ Synopsis

It is becoming clear that the cell nucleus is not only organized in domains but that these domains are also organized relative to each other and to the genome. Specific nuclear domains, enriched in different proteins and RNAs, are often found next to each other and next to specific gene loci. Several lines of investigation suggest that nuclear domains are involved in facilitating or regulating gene expression. The emerging view is that the spatial relationship between different domains and genes on different chromosomes, as found in the nucleolus, is a common organizational principle in the nucleus, to allow an efficient and controlled synthesis and processing of a range of gene transcripts. J.

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