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Nuclear mutations in Saccharomyces cerevisiae which increase the spontaneous mutation frequency in mitochondrial DNA

✍ Scribed by Johnson, Leland H.

Publisher: Springer
Year: 1979
Tongue: English
Weight: 482 KB
Volume: 170
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00267066

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✦ Synopsis

Fourteen mutants have been identified in which the frequency of spontaneous mutations in mitochondrial DNA is increased. As well as increasing the frequency of mutations to resistance to erythromycin, oligomycin and spiramycin, all the mutants also show changes in the frequency of spontaneous petite induction. None of the mutants has any effect on the frequency of spontaneous nuclear mutations. Nine of the mutants are in one complementation group and five are in another. The phenotype of both groups is caused by a single nuclear mutation.

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