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Nuclear matrix proteins in well and poorly differentiated human breast cancer cell lines

โœ Scribed by Shanti K. Samuel; Travis M. Minish; James R. Davie

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
175 KB
Volume
66
Category
Article
ISSN
0730-2312

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โœฆ Synopsis

The nuclear matrix, besides providing the structural support of the nucleus, is involved in various cellular functions of the nucleus. Nuclear matrix proteins (NMPs), which are both tissue-and cell type-specific, are altered with transformation and state of differentiation. Furthermore, NMPs have been identified as informative markers of disease states. Here, the NMP profiles from human breast cancer cell lines and breast tumours were analyzed using two-dimension gel electrophoresis. We identified NMPs that are associated with well and poorly differentiated human breast cancer cells in vitro and in vivo. Five NMPs (NMBC 1-5) were found to be exclusive for well-differentiated human breast cancer cells, while one NMP (NMBC-6) was found to be present only in poorly differentiated human breast cancer cells. The identification of these proteins suggests the potential use of nuclear matrix proteins as prognostic indicators. J.

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