Nuclear magnetic resonance and optical spectroscopic studies of block copolymers of polypeptides. I. Block copoly[(benzyl-L-glulamate)n: (benzyl-L-aspartate)m]

✍ Scribed by L. Paolillo; P. Temussi; E. Trivellone; E. M. Bradbury; C. Crane-Robinson

• Book ID: 102761081
• Publisher: Wiley (John Wiley & Sons)
• Year: 1971
• Tongue: English
• Weight: 733 KB
• Volume: 10
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.360101215

✦ Synopsis

Synopsis

111 a study of A-B type block copolymers of y beiizyl-bglutamate arid p-beiizgl-Laspartate use has been made of the observations: ( 1 ) that for pols aspartate esters t.he chemical shifts of the a-CH arid S H resoliarices are sensitive to the helix sense, (2) that in both helical and random coil coilformatioils the same resonances of poly-7-benzyl-b glutamate are well separated from those of poly aspartates. Since the sense of pol--& beiizgl-baspartate is very sensitive to the inclusion of y-benzj-1-L-glu tamate residues, the degree of overlap between the blocks can be studied by monitoring the helix sense of the aspartate. The ability of t,he S L I R met.hod to make separate observation of the two blocks removes the necessity of relying on an overall OltD parameter such as bo. The copolymers studied include those having lefthaiided, righthanded, and mixed-sense aspartate, con esporidiiig to differing degrees of overlap.

.,: i ,--).),I 0 1071 by Joliti Wiley Ot Sutis, Iiic.