Nuclear magnetic relaxation dispersion study of the dynamics in solid homopolypeptides

✍ Scribed by Yanina Goddard; Jean-Pierre Korb; Robert G. Bryant

• Publisher: Wiley (John Wiley & Sons)
• Year: 2007
• Tongue: English
• Weight: 251 KB
• Volume: 86
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.20714

✦ Synopsis

Abstract

The ^1^H nuclear magnetic relaxation dispersion profiles were measured from 10 kHz to 30 MHz as a function of temperature for polyglycine, polyalanine, polyvaline, and polyphenylalanine to examine the contributions of different side chain motions to the polypeptide proton relaxation rate constants. The spin‐fracton theory for ^1^H relaxation is modified to account for high frequency motions of side chains that are dynamically connected to the linear polymer backbone. The ^1^H relaxation is dominated by propagation of rare disturbances along the backbone of the polymer. The side‐chain dynamics cause an off‐set in the field dependence of the ^1^H spin‐lattice relaxation rate constants which obey a power law in the Larmor frequency in the limit of low and high magnetic field strength. © 2007 Wiley Periodicals, Inc. Biopolymers 86: 148–154, 2007.

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