The cellular localization of the precore/core and core proteins was studied by immunofluorescence following transfection of 143 thymidine kinase-negative (TK ) and Hep-G2 cells with expression constructs containing wild-type (hepatitis B e antigen [HBeAg]-positive) and precore mutant (HBeAg-negative
β¦ LIBER β¦
Nuclear Localization Signals in the Core Protein of Hepatitis C Virus
β Scribed by S.C. Chang; J.H. Yen; H.Y. Kang; M.H. Jang; M.F. Chang
- Book ID
- 115575829
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 610 KB
- Volume
- 205
- Category
- Article
- ISSN
- 0006-291X
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## Abstract IFNβΞ± combined with ribavirin is used for the treatment of chronic hepatitis C. However, HCV has mechanisms to resist the antiviral actions of IFNβΞ±. In order to study the molecular mechanisms of this resistance, the effect of __HCV__ gene expression on IFNβinduced nuclear import of STA