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Nuclear Localization Signals Enhance Germline Transmission of a Transgene in Zebrafish

✍ Scribed by Philippe Collas; Peter Aleström

Book ID
110268349
Publisher
Springer Netherlands
Year
1998
Tongue
English
Weight
117 KB
Volume
7
Category
Article
ISSN
0962-8819

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The development of vehicles driving foreign DNA into the cell nucleus is essential for effective cellular gene transfer applications. We report that noncovalent binding of nuclear localization signal (NLS) peptides to plasmid DNA enhances nuclear uptake of the DNA and promotes germline integration,