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Nuclear inositol lipids. Relationship between growth factor induced metabolic changes and protein kinase C activity

โœ Scribed by L. Cocco; S. Capitani; A.M. Martelli; R.F. Irvine; R.S. Gilmour; N.M. Maraldi; O. Barnabe; F.A. Manzoli


Book ID
118372159
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
332 KB
Volume
30
Category
Article
ISSN
0065-2571

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Platelet-derived growth factor (PDGF) and other agents that activate protein kinase C (PKC) rapidly alter cytosolic pH (pHJ and intracellular free calcium (Ca' +I,) in BALBk-3T3 fibroblasts. To define whether changes in pH, or [Ca++], are linked to PDGF-stimulated mitogenesis, these parameters were