A biphasic role of nuclear transcription
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Gianpaolo Papaccio; Antonio Graziano; Riccardo d'Aquino; Salvatore Valiante; Fab
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Article
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2005
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John Wiley and Sons
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English
⚖ 331 KB
## Abstract IL‐1β is an important mediator in the pathogenesis of type 1 diabetes both in vivo and in vitro and it has been shown to induce islet β‐cell apoptosis. Most of the IL‐1β effects seem to be mediated by NF‐κB transcription factor activation, but its role in the induction of islet β‐cell a