Nuclear Factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts
✍ Scribed by Laura A. Pérez-Casellas; Xiaoying Wang; Kristy D. Howard; Mark W. Rehage; Donna D. Strong; Thomas A. Linkhart
- Book ID
- 116272506
- Publisher
- Elsevier
- Year
- 2009
- Tongue
- English
- Weight
- 823 KB
- Volume
- 1789
- Category
- Article
- ISSN
- 1874-9399
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Osteogenic protein-1 (OP-1 or BMP-7) stimulates new bone formation in vivo and induces cell proliferation and differentiation of osteoblasts in vitro. Previous studies from our laboratory revealed that OP-1 led to a two-to threefold increase in steady-state insulin-like growth factor-I (IGF-I) and I