✦ LIBER ✦

Nuclear estrogen receptor II (nER-II) is involved in the estrogen-dependent ribonucleoprotein transport in the goat uterus I. Localization of nER-II in snRNP

✍ Scribed by Thomas Sebastian; Raghava Varman Thampan

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 194 KB
Volume: 84
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.1279

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✦ Synopsis

Abstract

Exposure of goat uterine nuclei to estradiol in vitro results in an immediate exit of ribonucleoproteins (RNP) from the nuclei to the medium. This RNP exit appears to be mediated by an estrogen receptor localized in small nuclear ribonucleoproteins containing U1 and U2 snRNA. Available evidence indicates that the estrogen receptor involved is not the ERα, but an alternative form, which is also a 66 kDa protein. This is the nuclear estrogen receptor II (nER‐II) that has no DNA‐binding capacity. The transport is estrogen‐specific since non‐estrogenic steroids do not stimulate the transport of the RNP where the receptor is localized. J. Cell. Biochem. 84: 217–226, 2002. © 2001 Wiley‐Liss, Inc.

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Nuclear estrogen receptor II (nER-II) is

Nuclear estrogen receptor II (nER-II) is involved in the estrogen-dependent ribonucleoprotein transport in the goat uterus: II. isolation and characterization of three small nuclear ribonucleoprotein proteins which bind to nER-II

✍ Thomas Sebastian; Raghava Varman Thampan 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 212 KB

## Abstract Three proteins of a goat uterine small nuclear ribonucleoprotein (snRNP) fraction, which bind to nuclear estrogen receptor‐II (nER‐II) have been isolated and purified. These are the p32, p55, and p60 of which p32 is the major nER‐II binding protein. Indirect evidence reveals that p32 bi