Nuclear enlargement – an early change produced in mouse epidermis by carcinogenic chemicals applied topically in the presence of a promoter
✍ Scribed by Andrew John Ingram; Paul Grasso
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 722 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0260-437X
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✦ Synopsis
Abstract
A series of 27 compounds, including 11 polycyclic hydrocarbons, 8 proximate carcinogens and 8 other compounds, were tested for their ability to induce epidermal nuclear enlargement in mouse skin. The materials were applied topically in methyl ethyl ketone containing 0.1% croton oil, repetitively for 3 days. Nuclear enlargement present on the fourth day was determined with the aid of a Quantiment image‐analysing computer. The results obtained indicated a close correlation between the topical carcinogenicity of the test compounds and their ability to induce epidermal nuclear enlargement in the presence of croton oil.