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Nuclear DNA content in breast carcinomas with neuroendocrine differentiation

✍ Scribed by Dr. Jahn M. Nesland; Erik O. Pettersen; Sophie D. Fosså; Johan Høsie; Jan Vincents Johannessen

Book ID
104505763
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
367 KB
Volume
150
Category
Article
ISSN
0022-3417

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✦ Synopsis

Sixty-one breast carcinomas (54 infiltrating ductal carcinomas and seven infiltrating lobular carcinomas) were immunostained with anti-NSE and analysed with respect to nuclear DNA content. Nine of the 23 NSE-positive breast carcinomas were diploid, five were triploid, six tetraploid and three pentaploid. Twenty-one of the 38 NSE-negative tumours were diploid, 10 were triploid, seven tetraploid, and none were pentaploid. Three of the eight histologically grade I tumours in the NSE-positive group were aneuploid, whereas all the six grade I tumours in the NSE-negative group were diploid. The results show that a proportion of breast carcinomas with neuroendocrine differentiation are aneuploid and that aneuploid tumours that are grade I histologically are found in the NSE-positive group and not in the NSE-negative group.

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