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Nuclear bromination in phloroglucinol derivatives

✍ Scribed by John A. Donnelly

Book ID
104249951
Publisher
Elsevier Science
Year
1959
Tongue
French
Weight
107 KB
Volume
1
Category
Article
ISSN
0040-4039

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✦ Synopsis

SINCE Koataneoki and Tembor' reported nuclear substitution in the bromination of chalconee derived from phloroglucinol (m, I), rorlcere2'3'4 have aesumed that it occurs in the 5'-position to form a tribromide which gives the 5-bromoaurone (II) with aqueoue ethanolio potaeeium hydroxide.

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## Abstract This study is the first to investigate the anticancer effects of the new phloroglucinol derivative (3,6‐bis(3‐chlorophenylacetyl)phloroglucinol; MCPP) in human colon cancer cells. MCPP induced cell death and antiproliferation in three human colon cancer, HCT‐116, SW480, and Caco‐2 cells