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Nuclear bile acid receptor FXR as pharmacological target: Are we there yet?

โœ Scribed by Salvatore Modica; Antonio Moschetta

Book ID
116466900
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
659 KB
Volume
580
Category
Article
ISSN
0014-5793

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The nuclear bile acid receptor FXR as a
The nuclear bile acid receptor FXR as a novel therapeutic target in cholestatic liver diseases: Hype or hope?
โœ Michael Trauner ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 216 KB ๐Ÿ‘ 2 views

Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. FXR-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transpo