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Nuclear architecture: Is it important for genome function and can we prove it?

✍ Scribed by Julio Mateos-Langerak; Sandra Goetze; Heinrich Leonhardt; Thomas Cremer; Roel van Driel; Christian Lanctôt

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
197 KB
Volume
102
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Gene regulation in higher eukaryotes has been shown to involve regulatory sites, such as promoters and enhancers which act at the level of individual genes, and mechanisms which control the functional state of gene clusters. A fundamental question is whether additional levels of genome control exist. Nuclear organization and large‐scale chromatin structure may constitute such a level and play an important role in the cell‐type specific orchestration of the expression of thousands of genes in eukaryotic cells. Numerous observations indicate a tight correlation between genome activity and nuclear and large‐scale chromatin structure. However, causal relationships are rare. Here we explore how these might be uncovered. J. Cell. Biochem. 102: 1067–1075, 2007. © 2007 Wiley‐Liss, Inc.

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