Nuclear androgen receptors in the prostate of male Praomys (Mastomys) Natalensis
โ Scribed by Smith, C.B. ;Ghanadian, R. ;Chisholm, G.D.
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 443 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0300-5623
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A steroid receptor protein was isolated from the cytoplasmic fraction of Mastomys prostate. Following in vivo and in vitro labelling of the tissue with tritiated testosterone or dihydrotestosterone, samples were analysed by gel exclusion chromatography or sucrose density gradient centrifugation. A s
Following the administration of labelled testosterone into 4-6 month old intact, or 24 h orchiectomized Praomys (Mastomys) Natalensis, the uptake of radioactivity by the prostate and other tissues was measured at different intervals. Two hours after the injection of the hormone, the concentration of
The presence of an androgen receptor protein in the supernatant preparation of the prostate from Rhesus monkey (macaca mulatta) is described. The molecular weight of this receptor protein was found to be 2.8 - 2.9 X 10(5) daltons. The levels of free and bound androgen receptors were measured in the