𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Noxytiolin and peritoneal adhesion formation

✍ Scribed by O. J. A. Gilmore; Clare Reid

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
319 KB
Volume
63
Category
Article
ISSN
0007-1323

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✦ Synopsis

Abstract

Clinical and experimental studies have suggested that intraperitoneal noxytiolin prevents adhesion formation. A reliable experimental animal model was therefore established and the effect of noxytiolin on adhesion formation was evaluated in a controlled trial using 80 rats. All 40 rats given Ringer solution developed adhesions, whereas in 7 out of 40 given noxytiolin no adhesions were found (P < 0Β·02). Noxytiolin reduced both the total and the mean number of adhesions formed (P < 0Β·2) and their mean length of attachment (P < 0Β·05). The anti-adhesive effect of noxytiolin may be due to its anticoagulant, cytotoxic or antibacterial properties.

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