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Noxa1 as a moderate activator of Nox2-based NADPH oxidase

โœ Scribed by Masahito Kawano; Kazuhiro Miyamoto; Yuki Kaito; Hideki Sumimoto; Minoru Tamura


Book ID
116178968
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
401 KB
Volume
519
Category
Article
ISSN
0003-9861

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## Abstract In Alzheimer's disease, extracellular deposits of amyloid ฮฒ~1โ€“42~ (Aฮฒ~1โ€“42~) may induce activation of microglial cells by releasing proinflammatory factors that contribute to the neurodegeneration process. Since the activation of cytosolic phospholipase A~2~ฮฑ (cPLA~2~ฮฑ) has been reporte