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Nox4 Regulates Cellular Survival by Modulating FOXO3A Activity and SIRT1 Expression

✍ Scribed by Lihong Cheng; Atsuko Tanaka; Calin Chiribau; Qianhong Qin; Dan Sorescu


Book ID
116340113
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
47 KB
Volume
16
Category
Article
ISSN
1532-8414

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## Abstract The goal of the investigation was to test the hypothesis that the phosphoinositide‐3 kinase (PI3K)/AKT signaling pathway regulates the expression of the major extracellular matrix component of the intervertebral disc, aggrecan, in nucleus pulposus cells. Primary rat nucleus pulposus cel