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Novobiocin in combination with high-dose chemotherapy for the treatment of advanced breast cancer: A phase 2 study

✍ Scribed by Hillary A. Hahm; Deborah K. Armstrong; Ting-Ling Chen; Louise Grochow; Jose Passos-Coelho; Steven N. Goodman; Nancy E. Davidson; M.John Kennedy


Book ID
117727863
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
158 KB
Volume
6
Category
Article
ISSN
1083-8791

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Twenty-three evaluable patients with advanced breast cancer were treated with MPA, 1,400 mg/m2 daily PO for the first 6 months, and 500 mg/m2 daily PO thereafter. The median total dose was 191,400 mg in 88 days, with the maximum dose given to date 522,600 mg in 282 days. Most patients tolerated high