𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novobiocin decreases SMYD3 expression and inhibits the migration of MDA-MB-231 human breast cancer cells

✍ Scribed by Xue-Gang Luo; Jia-Ning Zou; Shu-Zhen Wang; Tong-Cun Zhang; Tao Xi

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
275 KB
Volume
62
Category
Article
ISSN
1521-6543

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

SET and MYND domain‐containing protein 3 (SMYD3) is a histone methyltransferase that plays an important role in transcriptional regulation in human carcinogenesis, and heat‐shock protein HSP90A has been shown to increase the activity of SMYD3. We previously reported that overexpression of SMYD3 stimulated the migration of cells. In this study, we further found that novobiocin, a HSP90 inhibitor, could decrease the expression of SMYD3 and dose dependently inhibit the proliferation and migration of MDA‐MB‐231 human breast cancer cells. As a control, the short hairpin RNA (shRNA) targeting SMYD3 gene also showed similar effects with novobicin. This study is the first to show that novobiocin can inhibit the migration of breast cancer cells and such event may involve the downregulation of SMYD3. These findings might throw light on the development of novel therapeutic approaches to human cancers, and lend further understanding to the potential role of SMYD3 in human carcinogenesis. © 2009 IUBMB IUBMB Life, 62(3): 194–199, 2010

📜 SIMILAR VOLUMES

Oxytocin inhibits the proliferation of M
Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A
✍ Paola Cassoni; Anna Sapino; Nicoletta Fortunati; Luca Munaron; Bice Chini; Giann 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 81 KB 👁 1 views

Oxytocin (OT) inhibits the proliferation of breast-cancer cells in vitro via a specific G-coupled receptor. To elucidate the intracellular mechanism involved in this biological effect, different G-coupled receptor mediators have been investigated in untreated and OT-treated MDA-MB231 breastcarcinoma

Profilin-1 overexpression inhibits proli
Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation
✍ Li Zou; Zhijie Ding; Partha Roy 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 232 KB

## Abstract Profilin‐1 (Pfn1), a ubiquitously expressed actin‐binding protein, has gained interest in epithelial‐derived cancer because of its downregulation in expression in various adenocarcinoma. Pfn1 overexpression impairs tumorigenic ability of human breast cancer xenografts thus suggesting th

Glabridin, an isoflavan from licorice ro
Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway
✍ Ya-Ling Hsu; Ling-Yu Wu; Ming-Feng Hou; Eing-Mei Tsai; Jau-Nan Lee; Hsin-Lin Lia 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 405 KB

## Abstract **Scope:** In this study we first report the antimigration, antiinvasive effect of glabridin, a flavonoid obtained from licorice, in MDA‐MB‐231 human breast adenocarcinoma cells. **Methods and results:** Glabridin exhibited effective inhibition of cell metastasis by decreasing cancer c

Transforming growth factor-β1 enhances t
Transforming growth factor-β1 enhances the invasiveness of human MDA-MB-231 breast cancer cells by up-regulating urokinase activity
✍ Antonietta R. Farina; Anna Coppa; Antonella Tiberio; Antonella Tacconelli; Aless 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 201 KB 👁 1 views

Transforming growth factor-beta (TGF␤1) enhances human MDA-MB-231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit proliferation of this cell line. In contrast to basal invasion, which is plasmin-, urokinase (uPA)-, tissue-type plasminogen activator (t-PA)

Indole-3-carbinol inhibits MDA-MB-231 br
Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity
✍ Christine T. Brew; Ida Aronchik; Karena Kosco; Jasmine McCammon; Leonard F. Bjel 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 338 KB

## Abstract Indole‐3‐carbinol (I3C), a phytochemical derived from cruciferous vegetables such as broccoli and Brussels sprouts, has potent antiproliferative effects in human breast cancer cells and has been shown to decrease metastatic spread of tumors in experimental animals. Using chemotaxis and