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Novel α-Amino-Acid Phenolic Ester Derivatives with Intravenous Anaesthetic Activity.

✍ Scribed by Andrew Cooke; Alison Anderson; Jonathan Bennett; Kirsteen Buchanan; David Gemmell; Niall Hamilton; Maurice Maidment; Petula McPhail; Donald Stevenson; Hardy Sundaram


Publisher
John Wiley and Sons
Year
2003
Weight
173 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis of tetronic acid derivatives f
✍ Christos Mitsos; Alexandras Zografos; Olga Igglessi-Markopoulou 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 49 KB

## Abstract Active esters, produced by condensation of __O__‐acetyl protected α‐hydroxyacids with __N__‐hydroxysuccin‐imide, react with anions of active methylene compounds to afford β,β‐tricarbonyl derivatives which upon deprotection undergo cyclization to 3‐alkoxycarbonyl and 3‐acyl tetronic acid