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Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents

โœ Scribed by Aleem Gangjee, Roheeth K. Pavana, Wei Li, Ernest Hamel, Cara Westbrook, Susan L. Mooberry


Book ID
118808005
Publisher
Springer US
Year
2012
Tongue
English
Weight
343 KB
Volume
29
Category
Article
ISSN
0724-8741

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Synthesis of novel pyrrole and pyrrolo[2
โœ Mostafa M. Ghorab; Fatma A. Ragab; Helmy I. Heiba; Hanan A. Youssef; Marwa G. El ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 458 KB

a b s t r a c t Pyrroles and pyrrolo [2,3-d]pyrimidines were reported to act as potent anticancer agents, in this work, a series of novel 2-substituted-3-cyano-4-phenyl-pyrrole 5, 6, 11-18, and 5-phenyl-pyrrolo[2,3-d]pyrimidine derivatives 7-10, 19-24 bearing either sulfathiazole or sulfapyridine we