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Novel Vesicles Self-Assembled From Amphiphilic Star-Armed PEG/Polypeptide Hybrid Copolymers for Drug Delivery

✍ Scribed by Kang Wang; Hai-Qing Dong; Hui-Yun Wen; Meng Xu; Cao Li; Yong-Yong Li; Helen N. Jones; Dong-Lu Shi; Xian-Zheng Zhang

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 468 KB
Volume: 11
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.201000247

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✦ Synopsis

Abstract

A novel amphiphilic four‐armed [poly(ε‐benzyloxycarbonyl‐L‐lysine)]~2~‐block‐poly(ethylene glycol)‐block‐[poly(ε‐benzyloxycarbonyl‐L‐lysine)]~2~ hybrid copolymer has been prepared. The cytotoxicity study shows that the copolymer has good biocompatibility with no obvious inhibition effect on cell growth. The amphiphilic copolymers could self‐assemble to form vesicles in aqueous solution. DOX · HCl, as a hydrophilic drug, can be loaded into the vesicles, and then successfully internalized by human breast cancer MCF‐7 cells. Importantly, the DOX‐loaded vesicles show a greatly improved drug release behavior with a zero‐order release at the initial stage, suggesting a great potential as the carrier of hydrophilic drugs for controlled drug delivery. magnified image

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## Abstract A series of amphiphilic poly(L‐leucine)‐__block__‐poly(ethylene glycol)‐__block__‐poly(L‐leucine) (PLL‐PEG‐PLL) hybrid triblock copolymers have been synthesized. All the blocks in this system have good biocompatibility and low toxicity. The PLL‐PEG‐PLL copolymers could self‐assemble int