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Novel vascular targeting/disrupting agents: Combretastatin A4 phosphate and related compounds

✍ Scribed by Matthew M. Cooney; Jose Ortiz; Ronald M. Bukowski; Scot C. Remick


Book ID
107546371
Publisher
Current Science Inc.
Year
2005
Tongue
English
Weight
268 KB
Volume
7
Category
Article
ISSN
1523-3790

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## Abstract Combretastatin A4 (CA4) is a novel vascular disrupting agent that has promising clinical efficacy because of its ability to inhibit microtubule assembly and subsequently disrupt tumor blood flow. In this study, we demonstrate that mitogen‐activated protein kinases (MAPKs) are critically