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Novel therapeutics with enhanced biological activity generated by the strategic introduction of silicon isosteres into known drug scaffolds

✍ Scribed by Stephen Gately; Robert West


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
140 KB
Volume
68
Category
Article
ISSN
0272-4391

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Novel therapeutics with enhanced biologi
✍ Stephen Gately; Robert West 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB

## Abstract The strategic replacement of carbon with silicon within biologically prevalidated drug scaffolds can generate focused libraries of pharmaceutically relevant agents with novel, durable and marketable intellectual property. This approach can be cost‐effective and of lower developmental ri